Elphaba, a young woman with green skin, as she navigates life at Shiz University and forms an unlikely friendship with the popular Galinda. Their bond deepens as they encounter the Wizard of Oz, leading to a series of events that ultimately shape their destinies and transform them into the Wicked Witch of the West and Glinda the Good.
After challenging the Wizard's totalitarian regime in Oz, Elphaba must grapple with her identity as the "Wicked Witch of the West". Meanwhile, the Wizard has given Glinda the title "Glinda the Good" and a public status as the nation's defender against Elphaba. The two witches must make decisions that seal their fates in this second musical installment.